What is CLOVES?
CLOVES is an extremely rare progressive overgrowth disorder, affecting approximately 100 people worldwide. The symptoms vary from mild soft-tissue tumors to Vascular Malformations encompassing the spine or internal organs. All patients diagnosed with CLOVES have a large sandal gap. Patients do not have to exhibit every symptom in the list below; we often find that patients have a combination of these symptoms.
CLOVES stands for Congenital, Lipomatous, Overgrowth, Vascular Malformations, Epidermal Nevi, Spinal/ Skeletal Anomalies or Scoliosis.
There are a variety of signs and symptoms not covered in the CLOVES acronym - they include reddish/pinkish birthmark or port wine stain, a sandal gap in one or both feet, other skin abnormalities include prominent veins, and lymphatic vesicles (similar to blisters). Some patients with CLOVES have orthopedic challenges related to knees, feet, or hips, and may have different sized kidneys or even have an absent kidney. Wilms Tumor (childhood kidney cancer) is more common with Overgrowth disorders, so your doctor should recommend quarterly ultrasounds to monitor kidney abnormalities.
We want to offer a special thank you to Kristen Davis for defining CLOVES Syndrome.