CLOVES is an extremely rare progressive overgrowth disorder, affecting approximately 100 people worldwide. The symptoms vary from mild soft tissue tumors to Vascular Malformations encompassing the spine or internal organs. CLOVES Syndrome is closely linked to other overgrowth disorders like M-CM (Macrocephaly-Capillary Malformation) Syndrome, Klippel-Trénaunay-Weber Syndrome, and Proteus Syndrome.